Molecular and Cell Biology of Parasitic Protozoa

John H. Adams   Professor Ph.D. University of Illinois Postdoctoral, University of Queensland, National Institutes of Health

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Research summary.  The research in my lab focuses on the biology of malaria parasites and its remarkable ability to infect human populations.  Every 30 seconds someone dies from malaria, making it a leading cause of death and disease worldwide.  Plasmodium falciparum and P. vivax cause the majority of human malarial cases and are the primary species that my laboratory studies.  Most of the suffering inflicted by these protozoan parasites is from blood-stage development, which is initiated by the invasion of merozoites into susceptible erythrocytes.  Merozoite adhesion molecules or ligands, positioned on the merozoite surface and in the organelles of the apical complex, mediate the invasion process.  It is these molecules that determine infectivity and virulence.  Parasite stages in the mosquito also have similar molecules to the merozoite ligands that control invasion.  My research studies the function of these parasite ligands in the blood and mosquito stages and how they can be used for anti-malarial therapies. 

As a lab, we expect that a better understanding of Plasmodium's biology will enable us develop new ways to control malaria through vaccines and other prevention strategies. Major questions of my lab’s research include: a) how does allelic variation in the ligands help the parasite evade inhibitory immunity; b) what are the molecular interactions of the malarial ligand that are important to its function; and c) what mechanisms control expression of the invasion-related genes.  Incorporated into our lab-based studies are research links to laboratories in tropical regions endemic for malaria. Currently, we are studying malaria in endemic regions with collaborators in Papua New Guinea, southern Africa, and South America.

My research efforts are focused in three main projects:

1.  Duffy Binding Protein

2.  MAEBL

3.  Functional Genomics using piggyBac

 

For more general information about malaria, see my article "Malaria," Microsoft Encarta Online Encyclopedia.

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Current Outside Activities

2002-2006, Chair of the Executive Council, American Committee of Molecular, Cellular, & Immuno Parasitology of ASTMH

2000-2008, Editorial Board member, Infection and Immunity

2000-06, ASMTH Scientific Program Committee, Young Investigator Award Committee; subcommittee of Molecular, Cellular, & Immuno Parasitology

Funding sources: Natonal Institutes of Health, World Health Organization, The Burroughs Wellcome Fund

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Current teaching

BIOS 415 Medical & Veterinary Parasitology
BIOS 530 Immunobiology of Infectious Diseases

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Adams Lab Members

Bharath Balu, post doc

Fabian Saenz, doctoral student

Sarita Mendonca, doctoral student

Amy McHenry, doctoral student

Doug Shoue, senior technician

Angelina Zehrbach, technician

Sandi Kennedy, technician

Steve Maher, ND undergraduate reseacher

Ben White, ND undergraduate researcher

Brad Wisler, ND undergraduate researcher

Emily Obringer, ND undergraduate researcher

Andrea Shioleno, ND undergraduate researcher