Malcolm J. Fraser Jr. Professor Emeritus

Research Interests:

The Fraser laboratory merges research in Molecular Virology and Transgenic Engineering with the particular goals of advancing applications that improve the human condition. A major thrust of the research in this laboratory concerns the utilization of molecular approaches to understanding and manipulating virus genetics in ways that permit beneficial transgenic alteration of the hosts or host tissues to eliminate or preclude virus infection.

Biography:

• Rev. Julius A. Nieuwland, CSC, Professor of Biological Sciences, University of Notre Dame, IN 2011-Present
• Fellow, American Academy of Microbiology 2011-Present
• Fellow, Entomological Society of America 2009-Present
• Fellow, Royal Entomological Society of London 2008-Present
• Fellow, American Association for the Advancement of Science 2007-Present
• Postdoctoral, Texas A & M University, TX 1981-1983
• Postdoctoral, Penn State University, PA 1980-1981
• Associate Professor, Department of Biological Sciences, University of Notre Dame, IN 1989-2002
• Assistant Professor, Department of Biological Sciences, University of Notre Dame, IN 1983-1989
• Ph.D., The Ohio State University, OH 1981
• M.Sc. The Ohio State University, OH 1979
• B. Sc. Wheeling College, Wheeling, WV 1975

Recent Papers:

• Nawtaisong, P., Fraser, M. E., Carter, J. R., Fraser, M. J. Jr.. 2015. Trans-splicing group I intron targeting hepatitis C virus IRES mediates cell death upon viral infection in Huh7.5 cells. Virology 481, 223-34.
• Carter, J., Nawtaisong, P., Balaraman, V., Fraser, M. J. Jr. 2014. Design and analysis of hammerhead ribozyme activity against an artificial gene target. In: Daniel Lafontaine and Audrey Dubé (eds.), Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols. Methods in Molecular Biology 1103, 57-66. Springer, N.Y. 2014.
• Carter, J.R., Balaraman, V., Kucharski, C.A., Fraser, T.S., Fraser, M.J. Jr. 2013. A novel dengue virus detection method that couples DNAzyme and gold nanoparticle approaches. Virol. J. 10, 201.
• Teulé, F, Miao, Y. G, Sohn, B. H., Kim, Y. S., Hull, J. J., Fraser, M. J., Jr, Lewis, R. V., Jarvis, D. L 2012. Silkworms transformed with chimeric silkworm/spider silk genes spin composite silk fibers with improved mechanical properties. PNAS 103:3, 923-928
• M. J. Fraser, Jr. 2012. Insect transgenesis: Current applications and future prospects. Annu. Rev. Entomol. 57, 267-289.
• Carter, J. R., Keith, J. H., Barde, P. V., Fraser, T. S., M. J. Fraser, Jr. 2010. Targeting of Highly Conserved Dengue Virus Sequences with Anti-Dengue Virus Trans-Splicing Group I Introns. BMC Molecular Biology, 11, 84.
• Lynch, A.G., Tanzer, F., Fraser, M. J., Shephard, E. G., Williamson, A. L., Rybicki, E. P. 2010. Use of the piggyBac transposon to create HIV-1 gag transgenic insect cell lines for continuous VLP production. BMC Biotechnol.10, 30.
• Balu, B., C. Chauhan , S. P. Maher., D. A. Shoue, H. Wang, J. Kissinger, M. J. Fraser Jr., and J. H. Adams. 2009. piggyBac is an effective tool for functional analysis of the Plasmodium falciparum genome. BMC Microbiology, 9, 83.
• Nawtaisong, P., Keith, J., Fraser, T., Kolokoltsov, A., Davey, R., Higgs, S, Mohammed, A, Rongsriyam Y., Narumon, K, and M. J. Fraser, Jr. 2009. Effective suppression of Dengue Fever Virus in mosquito cell cultures using retroviral transduction of hammerhead ribozymes targeting the viral genome. BMC Virol. J. 6, 73.
• Carter, J. R., T. S. Fraser, and M. J. Fraser, Jr. 2008. Examining the relative activity of several Dicistrovirus intergenic IRES sites in uninfected insect and mammalian cell lines.J. Gen. Virol. 89, 3150-3155.