New Notre Dame research has been used to support the Orphan Drug designation for IT-139, a compound that when used in combination with chemotherapy has proved to be significantly more effective in treating pancreatic cancer than the current standard of care. The Orphan Drug program is administered by the Food and Drug Administration (FDA) and identifies promising drugs that are intended for the treatment of rare diseases, which impact fewer than 200,000 Americans at any time, or affect more than 200,000 people but are not expected to recover the costs of developing and marketing a treatment drug. Currently, pancreatic cancer has one of the lowest cancer survival rates, with one-year and five-year rates of 20 and 7 percent, respectfully.
The Indiana State Department of Health and the Indiana Clinical and Translational Sciences Institute (CTSI) has awarded Cody J. Smith, the Elizabeth and Michael Gallagher Assistant Professor of Biological Sciences and affiliated member of the Center for Stem Cells and Regenerative Medicine, a Spinal Cord and Brain Injury Research Fund (SCBIRF) grant.
The University of Notre Dame is highlighted in a new report on the importance of scientific research to economic growth.
The study, which was conducted by The Science Coalition, identifies more than 100 companies that exist due to funding received by academic researchers from federal government agencies, including the Department of Agriculture, Department of Energy, National Institutes of Health, National Institute of Standards and Technology, and National Science Foundation.
The WHO names Tuberculosis (TB) as one of the top 10 causes of death worldwide and over 95 percent of those deaths occur in low- and middle-income countries. To improve the global health community’s understanding of TB and provide information that could help treat it, Notre Dame researchers have developed a new strain of the bacteria along with a new method to better study this deadly disease.
Although it may seem simple to calculate, snowfall cannot be well measured by simply placing a yardstick in the ground. In actuality, snow measurement is much more complicated and oftentimes the most accurate snow measurement devices are costly. However, two Notre Dame graduate students are working to improve the snow measurement process in an effective and affordable manner.
When it comes to battling disease and maintaining healthy environments, DNA sequencing can be imperative to success. At the University of Notre Dame, the Genomics and Bioinformatics Core Facility (GBCF) supports research in many areas that increasingly rely on DNA sequencing, including cancer biology, vector-borne diseases, the development of drug and antibiotic resistance, monitoring invasive species, and much more.
Malcolm Fraser Jr., the University of Notre Dame’s Rev. Julius A. Nieuwland, C.S.C., Professor of Biological Sciences, is conducting research that utilizes the silkworm caterpillar’s silk gland to conduct mammalian-like protein production with the end goal of producing cost-effective biotherapeutic products, or therapeutic materials created utilizing recombinant DNA technology, that can be used to treat life-threatening and chronic diseases.
New research completed at the University of Notre Dame’s Environmental Research Center (UNDERC) – West indicates that as sinking brine shrimp cysts remain while many floating cysts are removed, the brine shrimp population is shifting to contain more sinking cysts.
The University of Notre Dame will attend the 2016 BIO International Convention, which is hosted by the Biotechnology Innovation Organization (BIO) from June 6 - 9, 2016 in San Francisco. Represented Notre Dame Research groups at the event include the Harper Cancer Research Institute (HCRI), the Center for Nano Science and Technology (NDnano), as well as Technology Transfer.
Today, April 25, is the annual World Malaria Day. This year’s theme – End Malaria for Good – seeks to build upon past successes in combatting this deadly disease, which killed over 435,000 people in 2015, and sustain this progress in order to truly “end malaria for good.” At the University of Notre Dame, Neil Lobo, a research associate professor of biological sciences and an Eck Institute for Global Health faculty member, is working to end malaria for good by focusing on the vectors that transmit the disease and how certain methods or interventions reduce malaria transmission.
When Europeans came to the New World in the 16th century, they brought measles and smallpox with them. Without the immunity Europeans had cultivated over the years, the native people in America quickly fell ill. Millions died as a result. Today, trees in the New World are also dying from diseases that were introduced through global trade started by the Europeans. However, trees are much more vulnerable than humans.
New research from the University of Notre Dame will be used to generate maps that provide time-sensitive, mosquito-to-human ratios that determine patterns of mosquito population dynamics for the Zika virus. The model outputs will be available online to provide users with the ability to find reported cases and estimated incidences by location of the virus to improve disease transmission and prevalence forecasts, which is critical to making accurate predictions and translating results into effective public health strategies.