Expert panel to discuss PFAS in firefighting gear with documentary film screening

Author: Jessica Sieff

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On April 29 (Saturday), the University of Notre Dame will host a screening of “BURNED: Protecting the Protectors” — a short documentary exploring the link between perfluorinated substances, known as “forever chemicals,” and decades of cancer in the firefighting community. The screening will take place at the DeBartolo Performing Art Center’s Browning Cinema at 6:30 p.m.

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Researchers in chemistry, engineering, physics and biological sciences honored by AAAS

Author: Jessica Sieff

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Five faculty members at the University of Notre Dame have been elected by the American Association for the Advancement of Science (AAAS) as lifetime fellows. The fellows include Patricia A. Champion, Jon P. Camden, Yih-Fang Huang, Ahsan Kareem and Rebecca Surman. All are being recognized for scientifically and socially distinguished achievements in their respective fields of study.

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Strength in numbers: Crowdsourcing challenge seeks new methods to combat drug-resistant malaria

Author: Jessica Sieff

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Three hundred and sixty participants from 31 countries participated in the Malaria DREAM Challenge, a crowdsourcing effort challenging anyone in the world to develop computational models for predicting emerging drug resistance to artemisinin, a widely used therapeutic considered the “last line of defense” against multi-drug-resistant malaria.   

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Microglia, cells thought restricted to central nervous system, are redefined in new study

Author: Jessica Sieff

Cody Smith Feature

Inside the body, disease and injury can leave behind quite the mess — a scattering of cellular debris, like bits of broken glass, rubber and steel left behind in a car accident. Inside the central nervous system (CNS), a region that includes the brain and spinal cord, it is the job of certain cells, called microglia, to clean up that cellular debris. Microglia have counterparts called macrophages that serve similar function outside the CNS in the peripheral nervous system (PNS), the region that contains most of the sensory and motor nerves.

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Scientists neutralize reactive nitrogen molecules to enhance cancer immunotherapy

Author: Jessica Sieff

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Immunotherapy — harnessing T-cells to attack cancer cells in the body — has given hope to patients who endure round after round of treatment, including chemotherapy, to little effect. For all of its promise, however, immunotherapy still benefits only a minority of patients — a reality driving research in the field for ways to improve the relatively new approach. One method for improving efficacy is the development of bio- and activity-based markers to better predict which patients will respond to immunotherapy and identify why some don’t. In a new study in the Proceedings of the National Academy of Sciences, researchers at the University of Notre Dame studying tumors in prostate cancer models found that nitration of an amino acid can inhibit T-cell activation, thwarting the T-cell’s ability to kill cancer cells.  

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As climate changes, so could the genes of the Eastern tiger swallowtail butterfly

Author: Jessica Sieff

Eastern Tiger Swallowtail Butterfly Feature

The reality of climate change poses a significant threat to global biodiversity. As temperatures rise, the survival of individual species will ultimately depend on their ability to adapt to changes in habitat and their interactions with other species. A new study published in the Proceedings of the National Academy of Sciences examines movement of the Eastern (Papilio glaucus) and Canadian (Papilio Canadensis) tiger swallowtail butterfly over a 32-year period within the geographic region where the two species mate, called the hybrid zone. The findings highlight the impact of changing climates and provide critical information for the protection and management of biodiversity.

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New study finds mycobacteria can sense presence of proteins that cause disease

Author: Jessica Sieff

Patty Champion Feature

Tuberculosis-causing mycobacteria use a select group of proteins known as virulence factors to transmit the disease, which infects roughly one third of the world’s population and causes 1.7 million deaths annually. Those proteins are cargo transported by molecular machinery, a microscopic gateway that promotes the survival of bacteria in the host. A new study by researchers at the University of Notre Dame and Michigan State University, published in the Proceedings of the National Academy of Sciences, reveals that mycobacteria can sense when this molecular machine is present.

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Researchers Use Light to Manipulate Mosquitoes

Author: Jessica Sieff

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Scientists at the University of Notre Dame have found that exposure to just 10 minutes of light at night suppresses biting and manipulates flight behavior in the Anopheles gambiae mosquito, the major vector for transmission of malaria in Africa, according to new research published in the journal Parasites and Vectors.

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Zika: Where are we now?

Author: Jessica Sieff

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Professors in Notre Dame’s Department of Biological Sciences and members of the Eck Institute reflect on the outbreak, the challenges presented by the virus and the work yet to be done to help health professionals and key decision makers protect their citizens.

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