Comparative Cardiovascular Physiology

Kenneth R. Olson

Professor, South Bend Center for Medical Education
Adjunct Professor, Biological Sciences
Ph.D., Michigan State University

The emphasis of this laboratory is on the mechanisms and evolution of blood pressure and fluid volume regulation. Fish are used in most studies because; 1) the fish cardiovascular system is the evolutionary prototype of all vertebrates, and 2) many of their physiological systems are uniquely sensitive to the environment and can thereby be manipulated experimentally. Similar studies are not possible with terrestrial vertebrates. Current studies are focused on the interactions of the autonomic nervous system, renin-angiotensin system, kallikrein-kinin system, atrial natriuretic peptides, and endothelium-derived vasoactive substances in the cardiovascular control and fluid volume regulation during fluid and salt loading and depletion. A variety of methods are employed, including in vivo instrumented fish, in vitro isolated organ and isolated smooth muscle studies. Techniques include cardiovascular surgery, radioisotope and HPLC methodology, second messenger RIA and electron microscopy.

Olson figure

Selected Publications:

Duff, D.W., Conklin, D.J. and Olson, K.R. (1997) Effect of atrial natriuretic peptide on fluid volume and glomerular filtration in the rainbow trout. J. Exp. Zool. 278:215-220.

Olson, K.R., Conklin, D.J., Farrell, A.P., Keen, J.E., Takei, Y.,Weaver, L. Smith, M.P. and Zhang, Y. (1997) Effects of natriuretic peptides and nitroprusside on venous function in trout. Am. J. Physiol. 273:R527-R539

Takei, Y., Fukuzawa, A., Itahara, Y., Watanabe, T.X., Yoshizawa-Kumagaye, K., Nakajima, K., Yasuda, A., Smith, M.P., Duff, D.W., and Olson, K.R. (1997) A new natriuretic peptide isolated from cardiac atria of trout, Oncorhynchus mykiss. FEBS Letters 414:377-380.

Zhang, Y., Weaver, L.J., Ibeawuchi, A. and Olson, K.R. (1998) Catecholaminergic control of venous function in the rainbow trout. Am. J. Physiol. 274:R1195-R1202.

Olson, K.R. (1997) The cardiovascular System. In: The Physiology of Fishes (D.H. Evans, ed.) CRC press, Boca Ratron, FL. p.129-154