Alex Perkins Eck Family Assistant Professor

Infectious disease epidemiology and population biology
Alex Perkins

Research Interests:

Research in the Perkins Lab applies mathematical, computational, and statistical approaches to better understand the dynamics of infectious disease transmission and control. Ongoing work is focused on dengue, malaria, chikungunya, and other diseases caused by mosquito-borne pathogens. These diseases are particularly interesting because of the complex ecology and epidemiology of the human and natural systems in which their pathogens are transmitted, and because of their critical and growing importance for global health. Some of the major themes of our ongoing research on these diseases include: (1) assessing the feasibility of targeted control and statistical limitations thereof; (2) developing and applying novel algorithms for inferring malaria transmission networks based jointly on epidemiological and parasite genetic data; and (3) using models to inform the design, analysis, and extrapolation of results from clinical trials of novel interventions.

 

Biography:

  • Eck Family Assistant Professor, University of Notre Dame 2014-Present
  • Concurrent Assistant Professor of Applied and Computational Mathematics and Statistics, University of Notre Dame 2015-Present
  • RAPIDD Postdoctoral Fellow, NIH Fogarty International Center and University of California, Davis 2011-2014
  • Ph.D. Population Biology, University of California, Davis 2011
  • B.A. Computational Ecology, University of Tennessee, Knoxville 2006

 

Recent Papers:

  • Achee NL, Gould F, Perkins TA, Reiner RC, Morrison AC, Ritchie SA, Gubler DJ, Teyssou R, Scott TW. 2015. A critical assessment of vector control for dengue prevention. PLOS Neglected Tropical Diseases 9:e0003655.
  • Lai S, Huang Z, Zhou H, Anders KL, Perkins TA, Yin W, Li Y, Mu D, Chen Q, Zhang Z, Qiu Y, Wang L, Zhang H, Zeng L, Ren X, Geng M, Li Z, Tatem AJ, Hay SI, Yu H. The changing epidemiology of dengue in China, 1990-2014: a descriptive analysis of 25 years of nationwide surveillance data. BMC Medicine.
  • Perkins TA, Metcalf CJE, Grenfell BT, Tatem AJ. 2015. Estimating drivers of autochthonous transmission of chikungunya virus in its invasion of the Americas. PLOS Currents Outbreaks 10 Feb 2015.
  • Perkins TA, Garcia AJ, Paz-Soldan VA, Stoddard ST, Reiner RC, Vazquez-Prokopec G, Bisanzio D, Morrison AC, Halsey ES, Kochel TJ, Smith DL, Kitron U, Scott TW, Tatem AJ. 2014. Theory and data for simulating fine-scale human movement in an urban environment. Journal of the Royal Society Interface 11:20140642.
  • Perkins TA*, Reiner RC*, Rodriguez-Barraquer I, Smith DL, Scott TW, Cummings DAT. 2014. A review of transmission models of dengue: a quantitative and qualitative analysis of model features. In: Dengue and Dengue Hemorrhagic Fever, eds. Gubler DJ, Ooi EE, and Farrar F. In press at CABI Publishing.
  • Smith DL, Perkins TA, Reiner RC, Barker CM, Niu T, Chaves LF, Ellis AM, George DB, Le Menach A, Pulliam JRC, Bisanzio D, Buckee C, Chiyaka C, Cummings DAT, Garcia AJ, Gatton ML, Gething PW, Hartley DM, Johnston G, Klein EY, Michael E, Lloyd AL, Pigott DM, Reisen WK, Ruktanonchai N, Singh BK, Stoller J, Tatem AJ, Kitron U, Godfray HCJ, Cohen JM, Hay SI, Scott TW. 2014. Recasting the theory of mosquito-borne pathogen transmission dynamics and control. Transactions of the Royal Society of Tropical Medicine and Hygiene 108:185-197.
  • Liebman KA, Stoddard ST, Reiner RC, Perkins TA, Astete H, Sihuincha M, Halsey ES, Kochel TJ, Morrison AC, Scott TW. 2014. Heterogeneous blood feeding patterns of Aedes aegypti in Iquitos, Peru. PLOS Neglected Tropical Diseases 8:e2702.
  • Perkins TA, Scott TW, Le Menach A, Smith DL. 2013. Heterogeneity, mixing, and the spatial scales of mosquito-borne pathogen transmission. PLOS Computational Biology 9:e1003327.
  • Smith DL, Perkins TA, Tusting LS, Scott TW, Lindsay SW. 2013. Mosquito population regulation and larval source management in heterogeneous environments. PLOS ONE 8:e71247.
  • Reiner RC*, Perkins TA*, Barker CM, Niu T, Chaves LF, Ellis AM, George DB, Le Menach A, Pulliam JRC, Bisanzio D, Buckee C, Chiyaka C, Cummings DAT, Garcia AJ, Gatton ML, Gething PW, Hartley DM, Johnston G, Klein EY, Michael E, Lindsay SW, Lloyd AL, Pigott DM, Reisen WK, Ruktanonchai N, Singh BK, Tatem AJ, Kitron U, Hay SI, Scott TW, Smith DL. 2013. A systematic review of mathematical models of mosquito-borne pathogen transmission: 1970-2010. Journal of the Royal Society Interface 10:20120921.
  • Perkins TA, Phillips BL, Baskett ML, Hastings A. 2013. Evolution of dispersal and life history interact to drive accelerating spread of an invasive species. Ecology Letters 16:1079-1087.
  • Perkins TA. 2012. Evolutionarily labile species interactions and spatial spread of invasive species. American Naturalist 179:E37-E54.