W. Matthew Leevy Research Associate Professor

In Vivo Imaging at the Crossroads of Biology, Biotechnology, and Pre-Clinical Research
W. Matthew Leevy

Research Interests:

I currently serve as the Director of Biological Imaging within NDIIF and lead an independent laboratory of talented staff, post-docs, and undergraduates. Our primary research interests are centered on the 3D printing of anatomical models derived from clinical and pre-clinical X-ray CT data sets. During the past three years we have accrued over a dozen patent submissions related to 3D printing. These have served as cornerstones for the creation of two start-up companies: In Vivo Concepts LLC and Biomedical Constructs LLC. My group is also active in the development of new in vivo imaging strategies to non-invasively monitor biological models of disease. Our work is currently funded through a combination of generous industrial sources and internal awards. We warmly welcome new collaborations, and execute pilot studies at no charge. Taken together, we operate a vibrant, collaborative, and entrepreneurial laboratory, and have broad experience in imaging technologies including whole animal fluorescence, bioluminescence, planar X-ray, PET, SPECT, MRI, and X-ray CT.



  • Research Associate Professor and Director of Biological Imaging, University of Notre Dame, IN 2014-Present
  • Research Assistant Professor and Director of Biological Imaging, University of Notre Dame, IN 2008-2014
  • Application Scientist, Carestream Health Molecular Imaging, New Haven, CT 2007-2008
  • Post-Doctoral Fellow, University of Notre Dame, IN 2005-2007
  • Ph.D. Biophysics, Washington University in Saint Louis, MO 2000-2005
  • B.S. Bioengineering, University of Illinois @ Urbana-Champaign 1996-2000


Recent Papers:

  • Smith, B. A.; Gammon, S. T.; Xiao, S.; Wang, W.; Chapman, S.; McDermott, R.; Suckow, M.; Johnson, J. R.; Piwnica-Worms, D.; Gokel, G. W.; Smith, B. D.; Leevy, W. M. “In Vivo Imaging of Acute Cell Death Using a Near-Infrared Fluorescent Zinc-Dipicolylamine Probe.” Mol. Pharm. 2011, 8(2), 583-590.
  • Smith, B. A.; Daschbach, Megan M.; Gammon, S. T.; Xiao, S.; Chapman, S.; Hudson, C.; Suckow, M.; Piwnica-Worms, D.; Gokel, G. W.; Leevy, W. M. “In Vivo Cell Death Mediated by Synthetic Ion Channels.” Chem. Commun. 2011, 47(28), 7977-7979.
  • Sasser, T. A.; Chapman, S. C., Li, S.; Hudson, C.; Orton, S. P.; Gammon, S. T.; Correcher, C.; Leevy. W. M. “Fat/Total Volume Ratio Measurements in Murine Obesity Models.” J. Vis. Exp., 2012, 62, 3680.
  • van der Veen, D. R.; Shao, J.; Chapman, S.; Leevy, W. M.; Duffield, G. E. “In Vivo Imaging of Diurnal Pattern in Brain and Heart Glucose Uptake in Mice.” PLoS One, 2012, 7(2), e31792.
  • van der Veen, D. R.; Shao, J.; Chapman, S.; Leevy, W. M.; Duffield, G. E. “A Diurnal Rhythm in Glucose Uptake in Brown Adipose Tissue Revealed by In Vivo PET-FDG Imaging.” Obesity, 2012, (26 March 2012) | doi:10.1038/oby.2012.78.
  • Chapman, S. E.; Diener, J. M.; Sasser, T. A.; Correcher, C.; Gonzalez, A. J.; Van Avermaete, T.; Leevy, W. M. “Dual Tracer Imaging of SPECT and PET Probex in Living Mice Using a Sequential Protocol. Am. J. Nuc. Med. & Mol. Img, 2012, 2(4), 405-414.
  • Orton, S. P.; Praagh, A. V.; Potenza, J. C.; Schmitthenner, H. F.; McLaughlin, W. Leevy, W. M.; “Broad Based, Non-Specific Tissue Absorbtion of Polycationic Near-Infrared Nanoparticles in Mice.” J. Biomed. Nanotech. 2013, 9, 77-85.
  • Sasser, T.A.; Van Avermaete, A. E.; White, A.; Johnson, J. R.; Chapman, S.; Van Avermaete, T.; Leevy, W.M. “Non-Invasive In Vivo Imaging of Bacterial Infection with Optical or Nuclear Probes.” Curr. Topics in Med. Chem. 2013, 13(4), 479 - 487.
  • Doney, E. L.; Krumdick, L. A.; Diener, J. M.; Wathen, C. A.; Chapman, S. E.; Van Avermaete, T.; Stamile, B.; Scott, J. E.; Ravosa, M. J.; Leevy, W. M. “3D Printing of Preclinical X-ray Computed Tomographic Data Sets.” J. Vis. Exp. 2013, March 22, (73), DOI 10.3791/50250. *Featured in Wired magazine
  • Davison, C. A.; Chapman, S. E.; Sasser, T. A.; Wathen, C.; Diener, J.; Schafer, Z. F.; Leevy, W. M. “Multimodal Optical, X-ray CT, and SPECT Imaging of a Mouse Model of Breast Cancer Lung Metasasis. Current Molecular Medicine, 2013, 1(13), 368-376.
  • Davison, C. A.; Matthew, R. Thau, Zellmer, V. R.; Chapman, S. E.; Diener, J. Wathen, C.; Leevy, W. M.; Schafer, Z. F. “Antioxidant Enzymes Mediate the Survival of Extracellular Matrix-Detached Breast Cancer Cells.” Cancer Research. 2013, 73(12), 3704-3715.
  • Wathen, C. A.; Foje, N.; Van Avermaete, T.; Miramontes, B.; Chapmen, S. E.; Sasser, T. A.; Kannan, R.; Leevy, W. M. “Preclinical X-ray Computed Tomography of Soft Tissue with Native, Injectable, or Ingestible Contrast.” Sensors. 2013, 13(6).
  • Wathen, C. A.; Caldwell, C,; Chanda, N.; Upendran, A.; Zambre, A.; Afrasiabi, Z.; Chapman, S. E.; Foje, N.; Leevy, W. M.; Kannan, R. “Selective X-ray Contrast Enhancement of the Spleen of Living Mice Mediated by Gold Nanorods.” Contrast Agents and Mol. Media, 2014, epub doi: 10.1002/cmmi.1617