Molecular Understanding and Immunotherapy of Metastatic Cancer

Know What Is This Cancer Immunotherapy And Why Is This Replacing Chemotherapy In Cancer Treatments

Principal Investigator

Xin Lu

Xin Lu, Ph.D.
John M. and Mary Jo Boler Assistant Professor

Department of Biological Sciences
Center for Rare and Neglected Diseases
Harper Cancer Research Institute
University of Notre Dame, Notre Dame, IN

Associate Member, Tumor Microenvironment and Metastasis Program
Indiana University Melvin and Bren Simon Cancer Center, 2017-Present

Phone: 574-631-6592 (office); 574-631-3960 (lab)
Email: xlu@nd.edu
Web: biology.nd.edu/people/xin-lu/

 

Brief Biography
  • John M. and Mary Jo Boler Assistant Professor, University of Notre Dame, IN 2017-Present
  • Instructor, Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 2014-2016
  • Jane Coffin Childs Postdoctoral Fellow. Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 2011-2014
  • Jane Coffin Childs Postdoctoral Fellow. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 2010-2011
  • Ph.D. (Molecular Biology), Princeton University, Princeton, NJ 2004-2010
  • B.S. (Biological Sciences), Tsinghua University, Beijing, China 2000-2004

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Lab Manager/Research Assistant

Seema

Seema Chaudhary
schaudha@nd.edu

Seema performs essential housekeeping experiments and lab duties, and helps maintain the smooth running of the lab.

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Postdoctoral Researchers

Missing in Action: Still need photo

Fang Liu, Ph.D.
fliu6@nd.edu

Dr. Liu is building novel mouse models and study the mechanisms of VHL syndrome, a rare cancer that causes serious problems in multiple organs. She is also interested in applying her expertise in immunology to design new cancer immunotherapy approaches.


Jing Yang

Jing Yang, Ph.D.
JYANG14@ND.EDU

My research interests: I am very interested in cancer immunotherapy. Currently, cancer vaccine, immunostimulatory agents, adoptive T cell therapy and immune checkpoint blockade are the most four effective immunotherapeutic approaches used in the clinic. But there are still many types of cancer resist to them. So to study the resistant mechanism of cancer immunotherapy and find more effective multiple immunotherapies are deeply attracted me.

My hobby: I like sport. Sport makes a man healthy, makes a man wise, make people happy.

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Graduate Students

Lu Placeholder

Sharif Rahmy
Sharif.Rahmy.1@nd.edu

An IBMS graduate student, Sharif identifies intrinsic and extrinsic mechanisms underlying resistance to immune checkpoint blockade therapy.


Yini Zhu

Yini Zhu
yzhu15@nd.edu

Life is such a beauty, I love and admire it, it makes me crazy. An IBMS graduate student, my project now is creating a new mouse model to have a better knowledge of how the smart but bad tumor escape from immune system.

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Research Visitors and Associates

Cheng

Xi Cheng
xcheng1@nd.edu

Xi is a visiting graduate student from China and he identifies novel combination strategies to treat aggressive prostate cancer.


Tianhe Huang

Tianhe Huang
thuang4@nd.edu

Tianhe is a visiting graduate student from China. A liked quote: "Stay hungry. Stay foolish"

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Undergraduate Students

Lu Placeholder

Yanting Luo
yluo3@nd.edu

I am interested in the molecules of life, the ways they work together to work organisms minuscule and massive, and how, when a few molecules’ working mechanisms go awry, diseases are triggered. Having gathered some experience exploring the genes of embryogenesis in C. elegans and working on the genetic engineering to express circular RNA with EGFP, I delved into cancer biology in Dr. Susan Gursky’s group through a study of the synergistic growth inhibition of AKBA and curcumin in colorectal cancer. I am currently in Dr. Xin Lu’s lab researching the mechanisms of penile cancer as well as potential treatments that stem from the discoveries.


Frederickson

Christian Frederickson
cfreder6@nd.edu

Jacqueline Weinrich

Jacqueline Weinrich
jweinric@nd.edu

Xiao Han

Xiao Han
xhan3@nd.edu

Missing in Action: Still need photo

Andrew Frear
afrear@nd.edu

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Alumni

Postdoctoral Fellows
  • Shan Feng, Ph.D. (2017-2018)
    Current Position: Mass Spec Facility Director, Westlake Institute for Advanced Study, Hangzhou, China
Undergraduate Students
  • William Morgenlander (2018), Honors Program, Outstanding Biological Scientist Award 2018
  • Sam Arroyo (2018)