Molecular Understanding and Immunotherapy of Metastatic Cancer


Know What Is This Cancer Immunotherapy And Why Is This Replacing Chemotherapy In Cancer Treatments


Principal Investigator

Xin Lu

Xin Lu, Ph.D.
John M. and Mary Jo Boler Assistant Professor

Department of Biological Sciences
Center for Rare and Neglected Diseases
Harper Cancer Research Institute
University of Notre Dame, Notre Dame, IN

Associate Member, Tumor Microenvironment and Metastasis Program
Indiana University Melvin and Bren Simon Cancer Center
Indianapolis, IN

Phone: 574-631-6592 (office); 574-631-3960 (lab)

Brief Biography
  • John M. and Mary Jo Boler Assistant Professor, University of Notre Dame, IN 2017-Present
  • Instructor, Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 2014-2016
  • Jane Coffin Childs Postdoctoral Fellow. Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 2011-2014
  • Jane Coffin Childs Postdoctoral Fellow. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 2010-2011
  • Ph.D. (Molecular Biology), Princeton University, Princeton, NJ 2004-2010
  • B.S. (Biological Sciences), Tsinghua University, Beijing, China 2000-2004

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Lab Manager/Research Assistant

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Katie Coleman

Katie is the Lab Manager and Research Assistant in the Lu Lab. She graduated with her bachelor's degree in Biology at Goshen College in 2010. After graduating, she spent six years working as a biochemist in the plant pathology and human healthcare industries. In the future, Katie plans to complete her graduate studies in cancer research and in the development of novel therapeutics.

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Postdoctoral Researchers

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Shan Feng, Ph.D.

As a chemical biologist, Shan is interested in studying chemical modifications caused by immunosuppressive myeloid cells in tumor infiltrating lymphocytes and other cells in the tumor microenvironment. Shan is also developing a project devising new antibody-drug conjugate (ADC) for personalized medicine of prostate cancer.

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Graduate Students (Rotation)

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Sharif Rahmy

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Undergraduate Students

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William Morgenlander

William Morgenlander is a Junior Physics and Biological Sciences double major in the Glynn Family Honors Program and the Biological Sciences Honors Program. William studies the molecular underpinnings of prostate cancer using transgenic mouse models.

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Sam Arroyo

I am a Biology and Spanish Supplementary major from Dallas, Texas. My interests include biological and clinical research, especially cancer research. I hope to become a pediatrician one day, and would like to continue to be engaged in research.

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Nat Mancuso

Nat Mancuso is a Biological Sciences and French major. He is an Evans Scholar, member of Judicial Council, and a member of the Glynn Family Honors Program. His current research in Dr. Lu’s lab focuses on combination therapies for penile cancer using mouse models.

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Regina Fox

I am a first year biology major in Saint Mary’s College with a passion for genetics and cancer research. With limited research experience, I am thrilled to be included in a molecular laboratory study at Notre Dame. After college, I plan to attend graduate school and obtain a PhD in genetics/genomics. Outside the lab, I am an active member of the Chemistry/Biochemistry Club and the University Band.

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Yanting Luo

I am interested in the molecules of life, the ways they work together to work organisms minuscule and massive, and how, when a few molecules’ working mechanisms go awry, diseases are triggered. Having gathered some experience exploring the genes of embryogenesis in C. elegans and working on the genetic engineering to express circular RNA with EGFP, I delved into cancer biology in Dr. Susan Gursky’s group through a study of the synergistic growth inhibition of AKBA and curcumin in colorectal cancer. I am currently in Dr. Xin Lu’s lab researching the mechanisms of penile cancer as well as potential treatments that stem from the discoveries.