The lab currently has openings for postdoctoral fellows, graduate students and undergraduate students. In particular, there are many intriguing projects for rotation students. Please contact Dr. Xin Lu (xlu@nd.edu) if you are interested in joining us to explore exciting opportunities of translational cancer research.

Novel Cancer Genes and Combination of Targeted and Immunotherapy

The goal of Dr. Xin Lu’s lab is to identify novel therapeutic targets and realize innovative combination therapy strategies to benefit cancer patients, through functional genomics, mouse modeling and therapeutics development (most recent publications: Wang*, Lu*, et al. Cancer Discovery, 2016; Lu et al. Nature, 2017). Located at the Department of Biological Sciences at the University of Notre Dame and affiliated with Indiana University Simon Cancer Center, the Lu lab is seeking highly motivated Ph.D. candidates with expertise and interests in one or more of following areas:

  • Cellular, biochemical or metabolic mechanism of cancer progression and metastasis, especially for but not limited to prostate cancer
  • Tumor microenvironment, tumor immunology and/or cancer immunotherapy (including combination immunotherapy)
  • Computational cancer bioinformatics, integrated analysis of oncogenomics and/or proteomics data and functional validation in cell culture and animal models.

A range of available projects includes: (1) Mechanistic understanding of immunosuppressive myeloid cells; (2) Metabolic reprogramming to enhance cancer immunotherapy; (3) Immunotherapy of prostate cancer bone metastasis; and (4) Gene identification and therapy development to treat castration-resistant prostate cancer.

Position Requirements

A doctoral degree in molecular biology, biochemistry, cell biology, immunology, bioinformatics or related field is required. A qualified candidate should hold or expected to hold (within ~ 6 months) a doctoral degree at the time of applying. Experience in mammalian cell culture, basic molecular cloning, cell biology and biochemistry techniques is required. Experience in RNAi, CRISPR, cancer biology, immunology, animal models, histopathology, and/or bioinformatics is highly desirable, but not required. Furthermore, a notable publication record, strong interpersonal and teamwork skills are also required.

Submit a current C.V. and names of 3 references to Dr. Xin Lu, Assistant Professor, Department of Biological Sciences, University of Notre Dame, IN 46556-0369, xlu@nd.edu .

The University of Notre Dame is an Affirmative Action/Equal Opportunity Employer. Women and minority candidates are encouraged to apply.