Research

Scholarly exploration across disciplines driving innovation

We tackle cutting-edge problems in biology through a departmental culture of intellectual openness, collegiality, and collaborative spirit.

We are focused on framing and executing a proactive, strategic plan for the department that will showcase our expertise and accomplishments, further enhance our culture of collaboration, and launch us into an era of excellence where the department’s new innovations and advances will serve to bring about lasting solutions to our most enduring global environmental and human health challenges.

Download 5 Year Departmental Strategic Plan

Research Areas

  • Anatomy & Physiology

    Our researchers in the department study adaptations to subzero temperatures, circadian control of metabolism, neuroendocrinology, evolution and pathobiology of the mammalian skull, and reproductive biology.

  • Cancer

    Our researchers investigate fundamental mechanisms that govern tumor initiation, cancer cell migration and invasion, tumor cell survival, metastasis, cell cycle control, the tumor microenvironment and chemoresistance.

  • Cellular & Molecular Biology

    We seek to understand how cells: work as individual units with a focus on membrane and cytoskeleton organization; organize into complex groups; coordinate their activities in organismal systems; and respond to extracellular signals and infectious agents.

  • Development & Regeneration

    Our researchers examine the mechanisms that direct cell growth, differentiation, organogenesis and regeneration of tissues such as blood, heart, retina, and kidney, relevant to our understanding of human development and disease.

  • Ecology & Environmental Biology

    We study the responses of organisms to the environment and the interactions among species in ecological communities. We work in terrestrial and aquatic ecosystems all over the world.

  • Entomology

    Our researchers work with insects, sometimes as models for basic physiology and development, sometimes to understand infectious disease, and sometimes to study population dynamics and the interaction of species such as herbivores and host plants.

  • Epidemiology & Population Biology

    Modeling of the many layers of information in biological systems has long been a mainstay of biology investigation. With data explosion, epidemiological models are vital for understanding and combating infectious diseases, shaping discovery.

  • Evolutionary Biology

    We use cutting-edge tools to understand evolutionary processes within whole genomes that lead to differences in organismal function. We use evolutionary differences to detect species in nature and predict their responses to environmental change.

  • Genetics & Genomics

    We engage modern genomic tools and approaches, including whole genome sequencing and 'transcriptome' analysis, to search for the genes and mutations that determine diseases, development, drug resistances and even natural variation and speciation.

  • Infectious & Vector-Borne Diseases

    Researchers investigate the cellular and genetic determinants of infectious diseases with emphasis on the host response to infection, modeling and epidemiology of disease and mechanisms of transmission and prevention.

  • Microbiology & Immunology

    Researchers work with bacterial and eukaryotic microorganisms and viruses, which cause a range of diseases including Dengue Fever, Malaria, Leishmaniasis, and Tuberculosis.

  • Neuroscience & Behavior

    Our researchers work in the areas of sensory neurobiology (especially vision and olfaction), stress and pain processes, circadian rhythms, control of social behaviors, and computational neuroscience.

  1. $249M Active Grant Portfolio Value (FY 2024)
  2. 143 Number of Active Grants (FY 2024)
  3. 1024 Five‑Year Publication Output (2020‑24)

Centers & Facilities

  1. Student twilling a liquid in a beaker

    Advanced Diagnostics and Therapeutics

    This center creates technologies and tools to combat disease, promote health, and safeguard the environment. AD&T’s investigators focus on the common purpose of advancing micro- and nano-scale research to improve lives around the world.

  2. Grad Student in Champion Lab

    Boler-Parseghian Center for Rare Diseases

    The Boler-Parseghian center for Rare Diseases exists to promote and support research and education in basic, translational, and clinical work on rare and neglected diseases at Notre Dame

  3. Center for Stem Cells_PP

    Center for Stem Cells & Regenerative Medicine

    The aim of this center is to provide a collaborative research space focused on the study, application, and ethical understanding of adult and induced pluripotent stem cells and their potential to treat and cure many diseases.

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  1. Center for Environmental Science & Technology (CEST) student

    Center for Environmental Science & Technology

    CEST is a cooperative effort between Notre Dame’s Colleges of Science and Engineering, fostering interdisciplinary environmental research and education by providing cutting-edge analytical technologies needed to address complex environmental problems.

  2. Center for Research Computing

    Center for Research Computing

    The CRC is a leader in cyberinfrastructure development and in research utilizing large amounts of data and computational power, providing supercomputer resources, services, and expertise to researchers within Notre Dame and external organizations.

  3. Freimann Life Sciences

    Freimann Life Science Center

    The Freimann Life Science Center (FLSC) is comprised of two state-of-the-art animal facilities equipped to house a wide variety of vertebrates, including: fish, with a large zebrafish population, frogs, rabbits and rodents.

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Research Opportunities

Discover dynamic research opportunities within the Department of Biological Sciences, tailored for both undergraduates and graduate students. Dive into hands-on projects exploring diverse facets of biology, from genetics to ecology. Engage with renowned faculty mentors to deepen your understanding and develop crucial research skills. Elevate your academic experience by contributing to groundbreaking discoveries in the vibrant field of biological sciences.