Molecular Understanding and Immunotherapy of Metastatic Cancer


Know What Is This Cancer Immunotherapy And Why Is This Replacing Chemotherapy In Cancer Treatments


Principal Investigator

Xin Lu

Xin Lu, Ph.D.
John M. and Mary Jo Boler Assistant Professor

Department of Biological Sciences
Center for Rare and Neglected Diseases
Harper Cancer Research Institute
University of Notre Dame, Notre Dame, IN

Associate Member, Tumor Microenvironment and Metastasis Program
Indiana University Melvin and Bren Simon Cancer Center, 2017-Present

Phone: 574-631-6592 (office); 574-631-3960 (lab)


Brief Biography
  • John M. and Mary Jo Boler Assistant Professor, University of Notre Dame, IN 2017-Present
  • Instructor, Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 2014-2016
  • Jane Coffin Childs Postdoctoral Fellow. Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 2011-2014
  • Jane Coffin Childs Postdoctoral Fellow. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 2010-2011
  • Ph.D. (Molecular Biology), Princeton University, Princeton, NJ 2004-2010
  • B.S. (Biological Sciences), Tsinghua University, Beijing, China 2000-2004

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Lab Manager/Research Assistant


Seema Chaudhary

Seema performs essential housekeeping experiments and lab duties, and helps maintain the smooth running of the lab.

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Graduate Students

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Sharif Rahmy

An IBMS graduate student, Sharif identifies intrinsic and extrinsic mechanisms underlying resistance to immune checkpoint blockade therapy.


Xi Cheng

Xi is visiting graduate student from China and he identifies novel combination strategies to treat aggressive prostate cancer.


Luis Avila

Luis is a rotation graduate student from IBMS program. He studies mechanisms of rare cancer.

Katie Morris

Kathryn Morris

Katie is a rotating student in the biological sciences program. She is interested in identifying new targets to improve clinical cancer treatments.

Yini Zhu

Yini Zhu

Life is such a beauty, I love and admire it, it makes me crazy. My project now is creating a new mouse model to have a better knowledge of how the smart but bad tumor escape from immune system.

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Undergraduate Students

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William Morgenlander

William Morgenlander is a Junior Physics and Biological Sciences double major in the Glynn Family Honors Program and the Biological Sciences Honors Program. William studies the molecular underpinnings of prostate cancer using transgenic mouse models.

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Sam Arroyo

I am a Biology and Spanish Supplementary major from Dallas, Texas. My interests include biological and clinical research, especially cancer research. I hope to become a pediatrician one day, and would like to continue to be engaged in research.

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Yanting Luo

I am interested in the molecules of life, the ways they work together to work organisms minuscule and massive, and how, when a few molecules’ working mechanisms go awry, diseases are triggered. Having gathered some experience exploring the genes of embryogenesis in C. elegans and working on the genetic engineering to express circular RNA with EGFP, I delved into cancer biology in Dr. Susan Gursky’s group through a study of the synergistic growth inhibition of AKBA and curcumin in colorectal cancer. I am currently in Dr. Xin Lu’s lab researching the mechanisms of penile cancer as well as potential treatments that stem from the discoveries.


Christian Frederickson

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  • Katie Coleman
  • Hui Ding
  • Natale Mancuso
  • Regina Fox