Molecular Understanding and Immunotherapy of Metastatic Cancer

Know What Is This Cancer Immunotherapy And Why Is This Replacing Chemotherapy In Cancer Treatments

Principal Investigator

Xin Lu

Xin Lu, Ph.D.
John M. and Mary Jo Boler Assistant Professor

Department of Biological Sciences
Center for Rare and Neglected Diseases
Harper Cancer Research Institute
University of Notre Dame, Notre Dame, IN

Associate Member, Tumor Microenvironment and Metastasis Program
Indiana University Melvin and Bren Simon Cancer Center, 2017-Present

Phone: 574-631-6592 (office); 574-631-3960 (lab)
Email: xlu@nd.edu
Web: biology.nd.edu/people/xin-lu/

 

Brief Biography
  • John M. and Mary Jo Boler Assistant Professor, University of Notre Dame, IN 2017-Present
  • Instructor, Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 2014-2016
  • Jane Coffin Childs Postdoctoral Fellow. Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 2011-2014
  • Jane Coffin Childs Postdoctoral Fellow. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 2010-2011
  • Ph.D. (Molecular Biology), Princeton University, Princeton, NJ 2004-2010
  • B.S. (Biological Sciences), Tsinghua University, Beijing, China 2000-2004

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Lab Manager/Research Assistant

Seema

Seema Chaudhary
schaudha@nd.edu

Seema performs essential housekeeping experiments and lab duties, and helps maintain the smooth running of the lab.

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Postdoctoral Researchers

Tianhe Huang

Tianhe Huang
thuang4@nd.edu

Tianhe is investigating prostate cancer from several angles. A liked quote: "Stay hungry. Stay foolish"

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Graduate Students

Golomb

Samantha Golomb
sgolomb@nd.edu

First-year BIOS student, rotating in the lab. Sam earned a BS in Microbiology from The Ohio State University and worked as a Process Development Associate at Bayer Pharmaceuticals for three years post graduation. While at Bayer, Sam realized her interests in drug discovery and research in therapeutics for cancer. She is currently working on an antibody drug conjugate project in the Lu Lab and plans to continue research in cancer treatment and the tumor microenvironment. Sam is a retired synchronized swimmer and likes to keep active by swimming and going to the gym. She also really likes cats!


Liu

Guoqiang “Orson” Liu
gliu4@nd.edu

Orson is a first-year Ph.D. student from IBMS program, rotating in the Lu lab. He devotes himself to investigating the mechanism of cancer progression and developing possible novel therapies for tumors. Now, he is specifically working on mechanism of androgen receptor(AR) inhibitor resistance and regulation of PD-L1 expression in prostate cancer by CRISPR screening.


Marrufo

Armando Magallanes Marrufo
amarrufo@nd.edu

Armando is a first-year Ph.D. student rotating in Dr. Lu’s lab. He is from Houston, Texas. Armando has a Bachelor of Science in Biology from Texas A&M University. While at Texas A&M, he began his first research experience in studying bacteriophages under Dr. Ryland Young. Inspired by his mother who is a breast cancer survivor, he grew interested in pursuing cancer research. Armando obtained his Master of Science degree in biomedical sciences at University of North Texas Health Science Center. While at UNTHSC, he pursued his research interest into cancer immunology in triple-negative breast cancer under Dr. Poruenlloor Mathew and Dr. Stephen Mathew. He plans to continue pursuing immunotherapy research with triple-negative breast cancer as well as other cancer models. Outside the lab, Armando enjoys playing the violin and training in Brazilian Jiu-Jitsu, gymnastics, and swimming butterfly. He is also very active in teaching and science educational outreach/advocacy through SACNAS (Society for Advancement of Chicanos/Hispanics and Native Americans in Science). Armando loves both Texas A&M Aggie Football and Notre Dame Football. Gig ‘em Aggies and Go Irish!


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Sean Murphy
smurph20@nd.edu

Sean is a first-year BIOS Ph.D. student, rotating in the Lu lab. He is from Arlington, Indiana. After receiving a Bachelor of Arts degree in Biochemistry/Molecular Biology from Wittenberg University he acquired a Masters of Science degree from Johns Hopkins University in Biotechnology while also working as a Research Technologist. His main interests include improving immunotherapy for cancer treatment as well as what role diet can play in treating and preventing cancer.


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Sharif Rahmy
Sharif.Rahmy.1@nd.edu

An IBMS graduate student, Sharif identifies intrinsic and extrinsic mechanisms underlying resistance to immune checkpoint blockade therapy.


Sun

Miaomiao Sun
msun4@nd.edu

BIOS graduate student in the Lu Lab. I am currently starting the project of mechanisms of VHL disease mutation in patient-derived fibroblasts


Wang

Meidan Wang
mwang13@nd.edu

A BIOS graduate student from China. My interest in cancer research drove me here and doing research related to Cancer Immunotherapy. I love to exercise in the gym which makes me energetic every day, and now I'm trying to develop some interest in football because this is the coolest sport at the ND. Go IRISH!


Yuting Zhang

Yuting Zhang
yzhang49@nd.edu

Yuting Zhang is a first-year IBMS Ph.D. student, rotating in the Lu lab. Now she is focusing on using CRISPR screening to study mechanism of regulation of PD-L1 expression in prostate cancer. Also, she loves Chinese classical dance and folk dance.


Yini Zhu

Yini Zhu
yzhu15@nd.edu

Life is such a beauty, I love and admire it, it makes me crazy. An IBMS graduate student, my project now is creating a new mouse model to have a better knowledge of how the smart but bad tumor escape from immune system.

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Research Visitors and Associates

X Wang

Xuechun Wang
xwang53@nd.edu

Xuechun is a visiting PhD student from Tongji University.


Jiling Wen

Jiling Wen, M.D.
jwen@nd.edu

Jiling Wen is a visiting scholar from Tongji University. He is an urologist in China. He is interested in genitourinary neoplasms.

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Undergraduate Students

Lu Placeholder

Yanting Luo
yluo3@nd.edu

I am interested in the molecules of life, the ways they work together to work organisms minuscule and massive, and how, when a few molecules’ working mechanisms go awry, diseases are triggered. Having gathered some experience exploring the genes of embryogenesis in C. elegans and working on the genetic engineering to express circular RNA with EGFP, I delved into cancer biology in Dr. Susan Gursky’s group through a study of the synergistic growth inhibition of AKBA and curcumin in colorectal cancer. I am currently in Dr. Xin Lu’s lab researching the mechanisms of penile cancer as well as potential treatments that stem from the discoveries.


Mittlesteadt

Jackson Mittlesteadt
jmittles@nd.edu

I have a strong passion for biology and the study of how systems of the body work together, particularly those of the nervous system. In addition, I am interested in how the components of these systems and other systems of the body at times grow unchecked in the development of cancer. I seek to further my understanding of the biological processes underlying neurology and oncology in the hope of becoming a pediatric physician conducting research concerning how systems both function and fail. I am a junior studying Biology and English. I have the privilege of working in Dr. Xin Lu’s lab assisting with genotyping of mice and other housekeeping experiments with the hope of taking up a research project in the coming semester.


Billy Porter

Billy Porter
wporter2@nd.edu

A freshman and Hesburgh-Yusko Scholar from Boston, Billy devotes himself to applying computer science in the field of medicine. He believes artificial intelligence not only lessens the limitations of sentient understanding but also can entirely replace humans, even experts, in many areas. With two previous years in experience conducting CyTOF research at Massachusetts General Hospital, Billy is currently in Dr. Xin Lu’s lab working with Sharif Rahmy to help statistically quantify and discover the reasoning behind the mechanisms regarding immune blockade therapy in a tumor microenvironment.


Frederickson

Christian Frederickson
cfreder6@nd.edu

Jacqueline Weinrich

Jacqueline Weinrich
jweinric@nd.edu

Xiao Han

Xiao Han
xhan3@nd.edu

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Alumni

Postdoctoral Fellows
  • Shan Feng, Ph.D. (2017-2018)
    Current Position: Mass Spec Facility Director, Westlake Institute for Advanced Study, Hangzhou, China
Graduate Students
  • Xi Cheng: Visiting PhD student (2018)
    Current Position: Physician scientist in Shanghai, China
Undergraduate Students
  • William Morgenlander (2018)
    Honors Program, Outstanding Biological Scientist Award 2018
  • Sam Arroyo (2018)