Job Openings and Opportunities

The lab currently has openings for postdoctoral fellows, graduate students and undergraduate students. In particular, there are many intriguing projects for rotation students. Please contact Dr. Xin Lu ( if you are interested in joining us to explore exciting opportunities of translational cancer research.

NOVEL CANCER GENE and therapy discovery in the era of cancer immunotherapy

The goal of Dr. Xin Lu’s lab ( is to identify novel therapeutic targets and realize innovative combination therapy strategies to benefit cancer patients, through mechanistic investigation, functional genomics, mouse modeling and therapeutics development (most recent publications: Wang*, Lu*, et al. Cancer Discovery, 2016; Lu et al. Nature, 2017; Feng…Lu, PNAS 2018). Located at the Department of Biological Sciences at the University of Notre Dame and affiliated with Indiana University Simon Cancer Center, the Lu lab is seeking highly motivated Ph.D. candidates with expertise and interests in one or more of following areas:

  • Cellular, biochemical or metabolic mechanism of cancer progression and metastasis, especially for but not limited to prostate cancer and breast cancer
  • Tumor microenvironment, tumor immunology and/or cancer immunotherapy (including combination immunotherapy)
  • Computational cancer bioinformatics, integrated analysis of oncogenomics and/or proteomics data and functional validation in cell culture and animal models.

A range of possible project topics includes: (1) Mechanistic understanding of immunosuppressive myeloid cells; (2) Metabolic reprogramming to enhance cancer immunotherapy; (3) Molecular mechanism of prostate or breast cancer metastasis; (4) Anti-metastasis and pro-metastasis functions of neutrophil subsets in cancer; (5) Gene identification and therapy development to treat lethal prostate cancer or breast cancer; (6) Novel mouse modeling and mechanistic understanding of rare cancers, especially VHL disease.


A doctoral degree in molecular biology, biochemistry, cell biology, immunology, bioinformatics or related field is required. A qualified candidate should hold or expected to hold (within ~ 6 months) a doctoral degree at the time of applying. Experience in mammalian cell culture, basic molecular cloning, cell biology, biochemistry or bioinformatics is required. Experience in RNAi, CRISPR, cancer biology, immunology, animal models, histopathology, and/or computational biology is highly desirable, but not required. Furthermore, a notable publication record, strong interpersonal and teamwork skills are also required. 

Interested candidates should send a current C.V. and names of 3 references to Dr. Xin Lu, Boler Assistant Professor, Department of Biological Sciences, University of Notre Dame, IN 46556-0369,

The University of Notre Dame is an Affirmative Action/Equal Opportunity Employer. Women and minority candidates are encouraged to apply.